Oxygenation is a problem with…? Ventilation is a problem with…?
SpO2/PaO2, CO2
Oxygenation is affected by what two parameters..?
FiO2, PEEP
What is the goal of oxygenation within the lungs?
Alveolar recruitment & diffusion
If a pt has hypoxemia, what should be adjusted on the vent? What should not be adjusted?
FiO2, PEEP; Do not adjust RR
Ventilation is affected by:
RR, Vt, Vm (minute ventilation)
What is the goal of ventilation?
CO2 removal
If a pt is hypercapnic, what should be adjusted on the vent? What should not be adjusted?
Adjust RR or Vt, not FiO2
Why is mechanical ventilation initiated?
O2 failure, CO2 failure, or need for airway protection
Why intubate w HYPOXEMIC resp failure?
Refractory hypoxemia despite supp O2
Why intubate w HYPERCAPNIC resp failure?
↑d PaCO2 w resp acidosis, inadequate Vm
Why intubate w ↑d WOB?
Tachypnea, accessory muscle use, impending fatigue
Why intubate for airway protection?
Depressed mental status, airway protection
Why intubate w neurologic impairment?
AMS affecting ventilation, elevated ICP requiring PaCO2 control
Why intubate w hemodynamic instability?
High O2 demand, ↓ cardiopulm reserve
Define FiO2.
Fraction of inspired oxygen delivered.
Define VT
Volume of gas that enters and leaves the lungs with each normal passive breath. WNL 6-8mL/kg IBW. ARDS 4-6mL/kg IBW.
Define Vm
Total volume of gas delivered per minute. Minute ventilation = VT × RR. Normal is 5-8 L/min.
Define PEEP
PEEP is Positive End-Expiratory Pressure: pressure in alveoli @ end of expiration. PEEP improves oxygenation but may ↑intrathoracic pressure →↓venous return → ↓cardiac output.
Define auto/intrinsic PEEP
Trapped alveolar pressure from incomplete exhalation, common in COPD/asthma
Define inspiratory:expiratory (I:E) ratio
Ratio of time spent in inspiration versus expiration. Normal setting on the ventilator is 1:2.
Define mean airway pressure
Average airway pressure over the respiratory cycle and key driver of oxygenation
Define peak inspiratory pressure (PIP)
Maximum airway pressure during inspiration. ↑PIP can indicate airway resistance or ↓ compliance.
Examples of↑PIP: kinked ETT, secretions, mucus plug, bronchospasm, asthma, COPD and ↓
compliance seen in pulmonary edema, ARDS, pneumothorax.
Define plateau pressure (Pplat)
Alveolar pressure measured during inspiratory pause. Keep < 30 cm H2O to prevent lung injury.
Inspiratory Flow
Average airway pressure over the respiratory cycle and key driver of oxygenation