1
Q
VIN definition
A
Chronic vulval skin disorder characterized by dysplastic changes of the squamous epithelium
2
Q
HSIL association
A
HPV
3
Q
Differentiated VIN
A
Associated with LS/LP
Older women
Higher risk of malignant transformation (60% SCC)
4
Q
Treatment
A
Excisional
Ablative (CO2 laser, cryotherapy)
Topical - Imiquimod cream 5% - response rate 58%
5
Q
Recurrence risk
A
30%
More likely with multi focal lesions, large lesions, smokers, immunocompromised
6
Q
Main risk factors for ca
A
Age>45 Raised solitary lesion Immunosuppression Presvious RT genital tract Previous VIN LS
Vulva
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