Virology

Question 1

What is the half life of CMV?

Answer 1

5-8 days

Question 2

In what patient should CMV blood PCR be trended? How often?

Answer 2

Transplant patients with CMV infection

Weekly

Question 3

How much should CMV go down for it to be an important decrease?

Answer 3

3 fold or 0.5 a log

Question 4

What resistance mutation in CMV confers ganciclovir resistance?

Answer 4

UL97

Question 5

What resistance mutation in CMV confers ganciclovir and cidofovir if selected for AND/OR foscarnet if selected for resistance?

Answer 5

UL54

–> Later mutation, UL97 is more common.

Question 6

Who should you consider testing for CMV viral resistance?

Answer 6

Those who have had 6 weeks of treatment for CMV including 2 weeks of full dose testing.