Viruses

Question 0

DNA viruses are ds EXCEPT

Answer 0

Parvo (ss)

Question 1

All DNA viruses

Answer 1

Are HHAPPPy

Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma

Question 2

DNA viruses are linear EXCEPT

Answer 2

Papilloma and polyoma (circular, supercoiled) and hepadna (circular, incomplete)

Question 3

DNA viruses are icosahedral EXCEPT

Answer 3

Poxvirus (complex)

Question 4

DNA viruses replicate in the nucleus EXCEPT

Answer 4

Pox (carries own DNA-dependent RNA polymerase)

Question 5

Enveloped viruses get their envelope from host’s plasma membrane EXCEPT

Answer 5

Herpesviruses - get their envelope from host’s nuclear membrane

Question 6

Naked viruses

Answer 6

CPR and PAPP

Calci, Picorna, Reo, Parvo, Adeno, Papilloma, Polyoma

Question 7

RNA viruses are ss EXCEPT

Answer 7

Reoviridae

Question 8

RNA viruses replicate in the cytoplasm EXCEPT

Answer 8

Influenza and retroviruses

Question 9

Positive stranded RNA viruses

Answer 9

I went to a RETRO TOGA party where I drank FLAVored CORONA and ate hippy (HEPE) CALcIfornia PICkles.

Question 10

Live attenuated vaccines

Answer 10

Smallpox, yellow fever, vzv, Sabin polio, MMR

No boosters needed, do not give to immunocompromised

Question 11

Killed vaccines

Answer 11

Rabies, influenza, Salk polio, HAV

Question 12

Recombinant vaccines

Answer 12

HBV, HPV

Question 13

Polyoma viruses

Answer 13

JC - junky cerebrum

BK - bad kidney

Question 14

HHV-6

Answer 14

Roseola

Question 15

Mononucleosis

Answer 15

EBV or CMV (negative monospot test)

Question 16

EBV “downy cells” are which lymphocyte? EBV infects which lymphocyte line?

Answer 16

T cells = “downy cells”

B cells are infected

Question 17

Negative stranded RNA viruses

Answer 17

Always Bring Polymerase Or Fail Replication

Arena, Bunya, Paramyxo, Orthomyxo, Filo, Rhabdo

Question 18

Segmented RNA viruses

Answer 18

Bunya, Orthomyxo, Arena, Reo

BOAR

Question 19

Parotitis, orchitis, aseptic meningitis

Answer 19

Mumps (Paramyxo)

Question 20

Koplic spots, descending maculopapular rash (head to toe), encephalitis, subacute sclerosing Pan-encephalitis years later

Answer 20

Measles (Paramyxo) rubeola

Question 21

Fever, postauricular adenopathy, LAD, arthralgia, fine truncal rash starts at head and moves down

Answer 21

Rubella (toga)

Question 22

Seal-like barking cough

Answer 22

Croup (Paramyxo)

Question 23

Bullet shaped capsid

Answer 23

Rabies - negri bodies in purkinje cells of cerebellum

Question 24

HBsAg marks

Answer 24

Active hep b disease

Question 25

Anti-HBsAg marks

Answer 25

Recovery from exposure

Question 26

HBcAg marks

Answer 26

New disease

Question 27

Anti-hBcAg

Answer 27

History of disease

Question 28

HBeAg marks

Answer 28

Increased contagiousness

Question 29

Anti-HBeAg marks

Answer 29

Decreased contagiousness

Question 30

Gp120

Answer 30

Attachment to host cell, binds CXCR4 or CCR5 and CD4

Question 31

Gp41

Answer 31

Fusion and entry to host cell

Question 32

Gag

Answer 32

Encodes capsid protein

Question 33

Env

Answer 33

Encodes for gp120 and gp41

Question 34

HIV genome

Answer 34

Diploid

Question 35

CCR5 mutation

Answer 35

Resistance or immunity to HIV

Question 36

CD4<400

Answer 36

Oral thrush

Question 37

CD4<200

Answer 37

JC virus reactivation - encephalopathy, PCP - pneumonia, cryptosporidium diarrhea

Question 38

CD4<100

Answer 38

Histoplasma capsulatum, esophageal thrush, toxoplasma gondii - cerebral abscesses

Question 39

CD4<50

Answer 39

Cryptococcus neoformans - meningitis (India ink stain), CMV retinitis or esophagitis, MAC TB like illness