1
Q
what is the role of CD40 in T cell activation?
A
- T cells recognize antigen on DC causing expression of CD40L on T cell
- CD40L binds to CD40 on DC causing secretion of cytokines
- Activated DCs stimulate T cell proliferation and differentiation
2
Q
TH1 cell:
signature cytokine(s)
immune reactions
A
IFNy
- macrophage activation
- IgG production
3
Q
TH2 cell:
signature cytokine(s)
immune reactions
A
IL-4, IL-5, IL-13
- mast cell, eosinophil activation
- IgE production
- macrophage activation
4
Q
TH17 cell:
signature cytokine(s)
immune reactions
A
IL-17A, IL-17F, IL-22
-neutrophilic, monocytic inflammation
5
Q
T regulatory cell:
signature cytokine(s)
immune reactions
A
TGF-b, IL-10, Foxp3
- inhibition of some T cell subsets
- help in IgA production
6
Q
T/F B and T lymphocytes come from a common bone marrow
A
True
7
Q
Where does B cell maturation occur?
A
in the bone marrow
8
Q
where does T cell maturation occur?
A
in the thymus
