Week 2

Question 1

Define hepatocellular injury

Answer 1

hepatocyte inflammation and damage

Question 2

Define Cholestatic

Answer 2

Impaired bile excretion

Question 3

what are the roles of Liver Tests?

Answer 3

• confirm a clinical suspicion of potential liver injury or disease
• distinguish between hepatocellular injury and cholestasis
• confirm medication appropriateness for hepatically cleared medicines

Question 4

What are the 4 enzymes used to assess liver injury?

Answer 4

1. ALT - alanine aminotransferase = liver
2. AST - aspartate aminotransferase = liver, heart, muscles, kidney, brain, RBCs
3. ALP - Alkaline phosphatase = liver, bone, placenta, biliary tract
4. GGT - gamma glutamyltransferase = liver, bile duct

Question 5

Elevated GGT indicates what?

Answer 5

cholestasis

Question 6

Elevated ALT indicates what?

Answer 6

• generalised damage to hepatocytes

Question 7

What is the importance of Bilirubin as a marker?

Answer 7

• liver conjugates and eliminates

Question 8

What is the importance of Albumin as a marker?

Answer 8

• synthesised by the liver

Question 9

Prothrombin Time (PT) function

Answer 9

Time to clot formation