SNS fight or flight
inc. mental activity bronchiolar dilation inc. RR inc. glucose inc. fatty acids inc. blood flow to skeletal muscles dilated pupils inc. HR inc. CO inc. arterial BP
PSNS rest and digest
eyes: accommodation for near vision: miosis
saliva: copious
Bronchi: constriction, inc. secretion
Heart: dec. rate, dec. BP
GI tract: inc. secretion, inc. peristalsis, dec. sphincter tone
Bladder: dec sphincter tone, inc. detrusor
Muscarinic effects: SLUG BAM
Salivation, Secretions, Sweating Lacrimation Urination GI upset Bradycardia, Bronchoconstriction, BM Abd. cramps, anorexia Miosis
Anticholinergic effects: ABCDS
Anorexia Blurry vision Constipation, confusion Dry mouth Sedation, stasis of urine
REMS
required risk management plans that use risk minimization strategies to ensure benefits > risk of Rx
- if drug causes liver failure, REMS would include monitoring liver function
direct-acting agonists
directly activate adrenergic receptors
indirect-acting agonists
enhancing release or blocking reuptake of norepi