What are the indications for pulmonary pharmacological interventions?
• Reduce bronchospasm • Reduce inflammation/allergic reaction • Reduce mucous production • Treat bacterial infection • Improve Oxygenation • Special Considerations: - Cough suppressant - Smoking cessation
What role does the sympathetic nervous system play in pulmonary?
Causes bronchodilation by increase cAMP, resulting in:
• Facilitates smooth muscle relaxation
• Inhibition of Mast Cells (inflammatory response and mucous production)
What role does the parasympathetic nervous system play in pulmonary?
Causes bronchocontrstriction by increasing cGMP resulting in:
• Facilitates smooth muscle constriction
• Facilitation of Mast Cells (inflammatory response and mucous production)
What is the primary method of drug administration to the lungs?
Primarily through inhalation (aerosol)
• May also be delivered orally or IV
What are the benefits of a Metered Dose Inhaler (MDI) or Dry Powder Inhaler (DPI)?
What are the limitations of a Metered Dose Inhaler (MDI) or Dry Powder Inhaler (DPI)?
How is an inhaler used properly?
• Shake for 2-5 seconds, remove cap, inspect inhaler
• If the inhaler hasn’t been used in a while, may need to prime it.
• Breathe out all the way.
• Start breathing in slowly through your mouth, then press down on the inhaler 1
time.
• Keep breathing in slowly, as deeply as you can.
• Hold breath and slowly count to 10.
• Wait about 1 minute before you take your next puff (Beta agonists only)
What is a spacer?
Also known as aerosol-holding
chambers, add-on devices and
spacing devices, long tubes that slow the delivery of medication from pressurized MDIs.
What are the characteristics of a spacer?
• Helps improve delivery of
medication.
• Often used for inhaled
corticosteroids and with younger patients
What is a nebulizer?
A device that mix drugs with air to form a fine mist that is inhaled through a mask
What are the characteristics of a nebulizer?
• Prolongs the delivery of the medication (10minutes)
• Originally thought to improve delivery of medication to distal bronchioles (Inconclusive)
• Useful for patients who cannot perform MDI technique correctly
- Young children
- Patients in acute distress
What are the general classifications of bronchodilators for pulmonary pharmacology?
What are the characteristics of bronchodilator: Epinephrine (Epi-Pen)?
What are the characteristics of Bronchodilator Adernergic Agonist: SABA-Short acting (rescue)?
What are the characteristics of Bronchodilator Adernergic Agonist: LABA-Long acting (maintenance)?
Salmeterol (Serevent)
• Time to effect: 10-20minutes
• Duration: 12hrs
What are the side effects for Bronchodilator Adernergic Agonist?
What does Bronchodilators: Cholinergic antagonists do?
Block the muscarine receptors in the bronchioles (LAMA)
What are the characteristics of Bronchodilators: Cholinergic antagonists?
• Drug of choice for COPD • Not used as often for asthma • Not absorbed well into bloodvstream • Less side effects than Beta Agnonists • Most Common: - Ipratropium (Atrovent) 3 4/day - Tiotropium (Spiriva) 1/day
What medicine provides a mix between SABA and LAMA?
Combivent
• Ipratropium bromide and
albuterol sulfate.
What are the characteristics of Bronchodilators: Methylxanthines?
Aka Xanthine deriviatives
• Common examples:
- Theophylline, Theobromine and caffeine
• Inhibit phosodiesterase enzyme
(PDE).
- Increases cAMP
- May also act as an adenosine antagonist
• Most common delivery route is oral, may also be injected (IV)
What are the side effects of Bronchodilators: Methylxanthines?
* Theophylline Toxicity: can cause arrthymias and seizures
What is the mechanisms of action of anti-inflammatory: glucocorticoids?
What are the characteristics of inhaled anti-inflammatory: glucocorticoids?
Used often for long term maintenance of Asthma
• Budenoside (Pulmicort), Beclemethasone (Belcovent), Fluticasone (Flovent)
What are the characteristics of oral anti-inflammatory: glucocorticoids?
Used often with acute infections, or exacerbations, 1-3weeks max
• Prednisone