Wegener's

Question 1

What do patients with Wegener’s develop?

Answer 1

necrotizing granulomatous inflammation in the nose, paranasal sinuses and lungs in addition to crescentic glomerulonephritis.

Question 2

What are the inflammatory features of Wegener’s?

Answer 2

It features very loose granulomas, with indistinct boundaries and scattered multinucleated giant cells.

Question 3

How many sites of granulomatosis are there in Wegener’s?

Answer 3

3

Question 4

What sre some of the accompanying symptoms of Wegner’s?

Answer 4

1. Rhinorrhea
2. Sinusitis
3. Nasopharyngeal mucosal ulcerations
4. mononeuritis multiplex
5. Skin lesions (papules, vesicles or purpura

Question 5

What are the treatments for Wegner’s?

Answer 5

1. Cyclophosphamide based treatments
2. STeroids
3. Plasmapheresis

Question 6

What does granulomatosis with polyangiitis (Wegner’s) cause?

Answer 6

Rapidly progressive crescentic glomerulonephritis.