weight gain key hx: timing
duration
relations to med changes, smoking cessation, depression
diet
weight gain key hx: assoc sxs
hypothyroidism sxs (fatigue, constipation, skin/hair/nail changes)
menstrual irregularities
hirsuitism
weight gain key hx: soc hx
sexual hx
alc/drug use
weight gain key PE
VS
complete exam (HEENT, CV, pulm, abd, MSK, neuro)
signs of Cushing syndrome (HTN, central obesity, moon face, buffalo hump, supraclavicular fat pads, purple abdominal striae)
edema resulting from water retention in renal dz
smoking cessation ddx
drug side fx hypothyroidism Cushing syndrome PCOS diabetes atypical depression
smoking cessation w/u
CBC BMP, glucose TSH 24-hour urine free cortisol dexamethasone suppression test
insulinoma ddx
reactive postprandial hypoglycemia
Cushing syndrome
pregnancy
insulinoma w/u
blood glucose plasma insulin after induced hypoglycemia glucose tolerance test 24-hour urine free cortisol urine b-hCG