1
Q
Epigenetic change associated with Queen Bee phenotype (Caste change in bees)
A
- HDAC found to be inhibited
- Leads to more histone acetylation and euchromatin formation
- Results in translation of genes for Queen Bee phenotype
2
Q
What type of mutations (x2) regarding epigenetic machinery are commonly mutated in cancer?
A
- Overexpression of CENP-A found in several types of cancer -> extensive mislocalisation of epigenetic machinery
- POT1 mutation oppose telomerase inhibition and have been observed in familial melanoma cases among other cancer types
B311
flashcards
Decks in class (12)
# Cards
-
L1: Prokaryotic Transcription19
-
L2: Coupling and small regulatory RNA's in Prokaryotes18
-
L3, Eukaryotic Transcription19
-
L4, Activators, Repressor and Chromatin in Euk. Gene Expression14
-
L5, Post Transcriptional Modifications of Gene Expression32
-
L6, Euk. Regulatory RNAs26
-
L7, Epigenetics25
-
L8, Centromeres and Telomeres23
-
L9, DNA repair defects (XP and NER)19
-
L10, MMR, Cockayne etc18
-
P1: Protein Expression Practical4
-
WS: Epigenetics2
