What does Xanthines do
–stimulate the ventilatory drive
–strengthens the diaphragm
–diureses and smooth muscle relaxation
–wake tup drug
Use of Xanthines: theophylline
Mangement of:
–Asthma
–COPD
–Apnea of prematurity in neonates
Xanthines
–Method of Admin: oral or IV
–Onset: slow
–Peak: Narrow
–Duration: Long
–Side effects: dizziness, headache, restlessness, anxiety, insomnia
–Therapeutic Range: 5-15 mcg/ml
Drugs of Xanthines
–Theophylline
–Aminophylline
–Caffeine
Xanithines: Caffeine
–Treat: Apnea of Prematurity (AOP)
–Caffeine citrate better choice
–Method of admin: IV does is 20mg/kg
Daily maintenance is 5 mg/kg
–Fewer side affects
the xanthine of choice to treat AOP is
–caffeine citrate