Yersinia

Question 1

Which yersinia is the major zoonotic pathogen?

Answer 1

Yersinia Pestis

Question 2

What disease does Yersinia Pestis cause?

Answer 2

plague

Question 3

What yersinia serotype causes enteric red mouth in fish?

Answer 3

Yersinia Ruckeri

*In rainbow trout- Fresh water fish

Question 4

Is yersinia lactose positive or negative?

Answer 4

negative

Question 5

Yersinia stable toxin is unique to which serotype?

Answer 5

Yersinia Enterocolitica

Question 6

What does yersinia stable toxin cause?

Answer 6

Leads to opening of calcium channels with flow of water and sodium

leads to Diarrhea

Question 7

What serotype of Yersinia has the murine toxin?

Answer 7

Yersinisa Pestis

Question 8

What species is Murine toxin toxic too?

Answer 8

mice and rats

Question 9

What is the purpose of the murine toxin in Yersinia pestis?

Answer 9

enhances the bacterial colonization in the flea midgut

Question 10

Cycle of Cat and Flea with Yersinia pestis

Answer 10

1. fleas become infected after feeding on mammal harboring the bacteria
2. rodents become infected when bitten by infected fleas
3. cats become infected by flea bites or consumption of infected rodents
4. cats can spread the plaque to humans via scratches, bites, and respiratory secretions
5. humans can also get the bacteria from flea bites

Question 11

What is the pathogenesis inside the flea with Yersinia pestis

Answer 11

1. flea feeds on infected host
2. bacteria survive in macrophages and induce apoptosis and Type III secretion system
3. bacteria secrete proteins for further survival
4. Extracellular survival via siderophores and capsule

*First intracelular than extracellular

Question 12

What species of flea is involved with Yersinia Pestis?

Answer 12

Xenopaylla cheopix- oriental rat flea

*cat and dog fleas (Ctenocephalides) do not typically transmit the bacteria

Question 13

What happens to humans infected with Yersinia pestis?

Answer 13

case fatality 15%

via feline infection, airborne, flea bite, or ingestions of infected meat

Question 14

What happens to cats that are infected with yersinia pestis?

Answer 14

lymphadenitis

fever, depression, anorexia, tonsillitis, pneumonia

symptomatic cases are often fatal

Question 15

Yersinia ____ has an incomplete LPS because they do not have the ____ antigen

Answer 15

Yersinia Pestis

No O antigen

Question 16

What kind of stain does Yersinia produce?

Answer 16

Bipolar staining

*looks like safety pin