Zofran

Question 1

Zofran Name

Answer 1

Ondansetron

Question 2

Zofran Class

Answer 2

Antiemetic agent

Question 3

Zofran MOA

Answer 3

Selectively blocks serotonin 5-HT receptors located in the CNS at the chemoreceptor trigger zone and in the peripheral nervous system on nerve terminals of the vagus nerve

Question 4

Zofran Indications

Answer 4

Nausea and vomiting

Question 5

Zofran Contraindications

Answer 5

• Hypersensitivity
• Use with caution in patients with hepatic impairment
• Avoid in patients with long QT syndrome

Question 6

Zofran Adverse Reactions

Answer 6

CNS: Headache, malaise, fatigue, dizziness, fever, sedation, extrapyramidal syndrome
CV: chest pain, arrhythmias
Resp: hypoxia
GI/hepatic: Diarrhea, constipation, abdominal pain, xerostomia, decreased appetite
Skin: rash

Question 7

Zofran Incompatibilities/Drug Interactions

Answer 7

Inducers or inhibitors of P450 drug metabolizing enzymes may alter the clearance of Ondansetron. No dosage adjustment is recommended.

Question 8

Zofran Adult Dosage

Answer 8

4-8mg IV slow push over 2-5 minutes

8mg PO ODT or tablet

Question 9

Zofran Pediatric Dosage (1month to 12 years)

Answer 9

Greater than 40 kg- 4 mg IV slow push over 2 – 5 minutes
Less than 40 kg- 0.1 mg/kg IV slow push over 2 – 5 minutes
4-12 years old 4 mg PO ODT

Question 10

Zofran Routes of Administration

Answer 10

IV, IM, PO

Question 11

Zofran Onset

Answer 11

Unknown, probably 10-30 minutes

Question 12

Zofran Peak Effects

Answer 12

Unknown

Question 13

Zofran Duration

Answer 13

Half life approximately 4 hours

Question 14

Zofran AZ Drug Box Minimum

Answer 14

Optional 4mg