1’ Biliary Cholangitis antibody
Anti Mitochondrial Antibody
Antimicrosomal antibody seen in
Hashimoto thyroiditis
40-60 yr - f - Pruritus - hepatomegaly - jaundice - liver cirrhosis symptoms - xanthoma over eyelid - abnormal lipid profile - Steatorrhea - osteopenia - SICCA -
Kayser - Fleiiischer Ring
1’ Biliary Cholangitis
IOC of 1’ Biliary Cholangitis
Liver biopsy
Mx of 1’ Biliary Cholangitis
UDCA (Ursodeoxycholic acid )
Obetocholic acid : if intolerance of UDCA
Cholestyramine
AntiH
Dronabinol : neutralizes endogenous opioids peptide
Naltrexone
Plasmapheresis
TOC : orthoptic liver transplant
D/D of 1’ Biliary Cholangitis
autoimmune hepatitis
1’ sclerosing Cholangitis
Sarcoidosis