10. Hypersensitivity

Question 1

Hypersensitivity

Answer 1

A pathological immune response for harmless or self antigen

Question 2

Hypersensitivity reaction I

Answer 2

IgE mediated - allergy (immediate)

Question 3

Hypersensitivity reaction II

Answer 3

Cell surface associated antigens + IgG mediated (4-6 hours)

Question 4

Hypersensitivity reaction III

Answer 4

Soluble antigen + IgG immuncomplex mediated (2-8 hours)

Question 5

Hypersensitivity reaction IV

Answer 5

Delayed type, T cell mediated (2-3 days)

Question 6

Two types of mast cells

Answer 6

1. Mucosal: Inhaled, ingested Ag

2. Connective tissue: Ag introduces through skin, intravenous

Question 7

Atopy

Answer 7

A genetic predisposition to exaggerated IgE production

Question 8

Frequent occurance of the allergic triad in atopic patients

Answer 8

1. Atopic eczema
2. Hay fever
3. Bronchial asthma

Question 9

Therapy of type I hypersen.

Answer 9

1. Avoidance of allergen
2. Desensitization/hyposensitization: administering small amount of allergen and increasing the dose of antigen slightly over time
3. Drug treatment

Question 10

Rh- incompatibility

Answer 10

1. RhD- mother has a baby who is RhD+
2. Postpartum: Mothers B-cells stimulated to produce anti-RhD Ab -> memory B-cells
3. Another pregnancy with an RhD+ fetus -> lysis of baby’s RBCs