1.1 Phys definitions

Question 1

What is the equation for Mean Arterial Blood Pressure?

Answer 1

MABP= (HR*SV) *TPR

• HR= Heart Rate
• SV= Stroke Volumne
• TPR= total peripheral resistance

Question 2

What controls HR, SV, TPR?

Answer 2

• HR controlled by sym. nervouse system
• SV controlled by preload and contractility
• TPR controlled by arterial vasoconstriction

Question 3

In physiology you will learn that all of the systems are linked and interdependent.
Meaning?

Answer 3

Dysfunction in one system leads to compensation and/or dysfunction in other systems.

Question 4

Physiology vs pathophysiology?

Answer 4

Phys= normal function. is what are automatic process, why, and how they are achieved. 
*Pathophys= ABnormal function. is what happens when automation process breaks down

Question 5

intercellular vs intracellular

Answer 5

inter= BETWEEN cells
intra= within cells

Question 6

What are the 3 forms of intercellular communication we talked about?

Answer 6

1) nervouse communication
2) humoral communication
- telocrine
- paracrine
- autocrine
3) cell-to-cell communication
- juxtacrine
- gap junction

Question 7

benefit of nervous communication

Answer 7

QUICKLY get info from A to B

Question 8

explain telocrine communication?

Answer 8

humoral; info sent FAR away

Question 9

explain paracrine commun.?

Answer 9

humoral; info sent to an adjacent NON-touching cell

Question 10

explain autocrine comm.?

Answer 10

humoral; info binds to receptor on OWN surface

Question 11

humoral communication depends on? Ex?

Answer 11

forms depend on distance

*Ex: blood

Question 12

explain juxtacrine commun?

Answer 12

cell-to-cell; one cell has a cellular process that binds & engages with a receptor on another cell, physical link

Question 13

explain gap junctions?

Answer 13

cell-to-cell; fused together for immediate comm

Question 14

internal milieu means=

Answer 14

extracellular composition= internal invironment

Question 15

extracellular vs intraceullar fluid? how much of each makes up total body water?
What is the rule?

Answer 15

• intra= INSIDE cell; 2/3 TBW
• extra= OUTSIDE cell; 1/3 TBW
  60: 40:20 rule

Question 16

two types of extraceullar fluid? which one do you have more of?

Answer 16

1) interstitial fluid= fluid surrounding cells NOT in vessels; about 3.5-4x more
2) plasma= fluid surrounding cells IN a vessel

Question 17

homeostaticallycontrolled factors are regulated by?

Answer 17

sensor-effector-negative feedback loops; often bidirectionally

Question 18

reflex

Answer 18

a specific involuntary, unpremediated, “built in” response to a stimulus

Question 19

arc

Answer 19

the pathway and components of the reflex; each arc has afferebt (sensing) and efferent (motor) limbs

Question 20

bidirectional control

Answer 20

ability to BOTH increase a controlled factor that is below its normal range AND to decrease a controlled factor that is above its normal range

Question 21

controlling temp of body and glucose levels are examples of?

Answer 21

sensor effector negative feedback loops

Question 22

set points for homeostasis can be ____ rather than static?

Answer 22

dynamic

Question 23

many disease processes, signs, and symptoms are due to?

Answer 23

homeostatic dysregulation

Question 24

protein activity is regulated by?

Answer 24

microenvironments “turning enzymes on and off”

Question 25

why/how are homeostatically controlled factors regulated?

Answer 25

1) proteins function by binding stuff 2) proteeins function optimally within set points/narrow ranges 3) Anything that affect binding characteristicsof protein affect its function/activity (temp, pH, salt)

Question 26

enzymes, membrane and nuclear receptors, channel pores, antibodies are all?

Answer 26

proteins