When can prophylactic clexane be given post epidural catheter removal
a) 2 hrs
b) 4 hrs
c) 6hrs
d) 12hrs
e) 24hrs
4 hrs
ASRA guidelines: https://rapm.bmj.com/content/early/2025/01/21/rapm-2024-105766
2021 BJA recommendations
2019 Stanford guidelines
Temperature measurement during cardiopulmonary bypass - which is most accurate:
A) Nasopharynx
B) Oxygenator arterial outlet
C) Oxygenator venous inflow
D) Bladder temp
E) PA Cath
Rewarming: nasopharyngeal done in practice for cerebral
Pulmonary artery > nasopharyngeal (~10-20cm in) > bladder»_space; tympanic
- in terms of accuracy
gold standard for continuous core temperature monitoring since this has been shown to be ‘closest to the temperature in the high internal jugular vein,’ which is the venous drainage of the brain. 2018 Indian resp journal
pulmonary artery ≥ nasopharynx > forehead > bladder > fingertip.
2007 Journal of Thoracic surgery: ranks reliability for DHCA
“Pulmonary artery (PA) or nasopharyngeal temperature recording is reasonable for weaning and immediate postbypass temperature measurement.” 2015 Society of Thoracic Surgeons doesn’t differentiate between the two
Giving DDAVP to VWD type 3
a) No effect
b) If they’ve had a positive challenge test
c) Effective
No effect
- type 1: helps
- 2a maybe
- 2b contraindicated
Give TXA to each type - previous MCQ on what 1st thing to give is
In Type 3 vWD, where there is a severe deficiency or absence of vWF, desmopressin is not effective since there is insufficient vWF to release. These patients typically require factor concentrates (vWF-containing concentrates) for treatment instead of desmopressin.
Ref: https://www.rch.org.au/clinicalguide/guideline_index/Von_Willebrand_Disease_vWD/ and ChatGPT
Post amputation, most effective at treating post op neuropathic pain?
a. NA
b. Regional ?
c. Ketamine
d. Gabapentinoid
e. TCA
Answer = Phenytoin
Methadone; Metabolised CYP3A4 and CYP2D6
Interactions
Phenytoin/Carbazapine/Rifampicin classic inducers of CYP450’s = Increased methadone metab = Decreased DOA
Grapefruit/Erythromycin/fluconazole = inhibit CYP450s = Decreased meth metab = Increased DOA.
Warfarin - small risk INR inc
Citalopram = risk QT and serotenergic syndrome.
Codeine = risk opioid resp drepssion.
Chat GPT/deranged
Alternate remembered: which is best at decreasing chronic pain after amputation?
a. NA
b. Regional
c. Ketamine
d. Gabapentinoid
e. TCA
TCA if chronic
- regional for acute postop pain
Answer = Gabapentinoid (acute and chronic) (pregabalin > gabapentin)
Treatment amputation pain = IV morphine, oral morphine, ketamine, gabapentin treat phantom pain compared to placebo.
Peroperative epidural, peripheral nerve catheter treat phantom limb pain (but not neuropathic?)
Perioperative regional catheter treats pain but does not precent PLP
Source = APMS handbook and uptodate reviewed. Complex to answer.
Amitriptyline: lowest NNT for neuropathic (w/o amputation)
Parkinson’s with apomorphine infusion which antiemetic to use?
a) Ondansetron
b) Droperidol
c) Prochlorperazine
d) Metoclopramide
e) Cyclizine
Cyclizine
What has the most favourable number needed to treat?
a. Paracetamol
b. Paracetamol + codeine
c. Paracetamol + ibuprofen
d. codeine
e. ibuprofen
Paracetamol + ibuprofen
Oral combinations of paracetamol/ibuprofen provide superior analgesia to paracetamol/codeine; both combinations are more effective than the individual medicines and have a dose-response effect (S) (Level I [Cochrane Review]). ANZCA Pain book.
Intra-aortic balloon pump, deflation when?
a. Start of R wave
b. Peak of R wave
c. Start of T wave
d. Peak of T wave
b) Peak of R wave
deflates at peak of R wave
inflates at peak of T wave
Child in ED needs procedural sedation. Unable to get IV access - What is the IM dose of ketamine?
1 mg/kg
2 mg/kg
3 mg/kg
4 mg/kg
5 mg/kg
IM ketamine: 4mg/kg then 2mg/kg topup after 10-15 mins (max 6mg/kg)
- peak effect 5 mins, duration 15-30 mins
- 5mg if ketamine dart
- 4-6mg/kg if adult (as per QHealth)
RCH ketamine: onset 3-4 mins, duration: 15-30min
Perth Children’s ketamine: peak effect 5 mins, duration 15-30mins
IV ketamine 1-1.5mg/kg over 1-2mins before procedure (RCH/Perth Children’s)
- peak effect 1-2 mins, duration 5-10 mins
- increased AEs with >2.5mg/kgRCH: 4mg/kg initially, can give further 2mg/kg to max 6mg/kg if insufficient effect
IM suxamethonium in paeds, onset of maximal effect?
a. 30 seconds
b. 1 minute
c. 2 minutes
d. 4 minutes
e. 10 minutes
Seems like onset 1-2 mins. peak effect 4 mins.
AoA 2007: the 3–4 min required for maximal twitch depression after 4 mg/kg
Sims: “onset is within 60 s and duration under 20 min. The deltoid muscle is the best site for injection.”
Nerve topicalised between epiglottis and VC:
a) Internal branch of superior laryngeal nerve
Internal branch SLN above cords
Recurrent laryngeal below cords
A thoracic regional technique that will NOT provide analgesia for sternal fractures is a:
a. PECS I
b. PECS II
c. Parasternal intercostal nerve block
d. Transversus throacic plane block
PECS 1
between pecs major and pecs minor - blocks lateral and medial pectoral nerves; doesn’t cover more medial sternum
Fibrinogen target in PPH?
a) 2
b) 1.5
c) 1
d) 2.5
2.5g/L -> QLD Health 2024 PPH/SA Health 2021
2g/L
“In the obstetric patient, the aim should be to keep fibrinogen >2 g/L” 2015 BJA obstetrics
Usual fibrinogen in parturient ~8g/L!
Max safe ropivacaine dose in adults:
450mg
650mg
770mg
1080mg
770mg
400mg if bupivacaine/24hrs
ANZCA endorsed guideline of GLP-1 perioperative management:
a) Do not cease periop and treat as unfasted
b) Cease 4 week
c) Cease 1 week
d) Various other options
Question written prior to updated guidelines
Preprocedure:
- Don’t cease GLP-1RAs (risks of hyperglycaemia and weight gain)
- 24hr clear diet (is enough to be considered fasted) then 6hr fasting
If on solids <24hrs, options are:
1) Gastric US
2) IV erythromycin 3mg/kg (caution prolonged QT)
3) Consider unfasted: GA ETT RSI (or minimal sedation)
4) Defer procedure
https://www.anzca.edu.au/getContentAsset/0f35028e-e371-4220-a49a-ddee877051c8/80feb437-d24d-46b8-a858-4a2a28b9b970/Clinical-Practice-Recommendations-Periprocedural-GLP-1RA-use-Apr-2025.pdf
How to prevent microschock
a) Equipotential earthing
b) LIM
c) RCD
d) Fuse
Equipotential earthing
Luke
Microshock
- 100uA threshold to cause VF.
- prevention = Equipotential earthing.
Macroshock
- 100mA to cause VF.
- Prevention = Body protected devices, LIM RCD, Class I and II equipment.
Minimum current for macroshock to cause VF
a) 10 microA
b) 100 microA
c) 10 mA
d) 100 mA
100mA
50-100 microA for microshock VFib
Intralipid max total dose?
a. 6ml/kg
b. 10 ml/kg
c. 12 ml/kg
d. 15ml/kg
e. 21ml/kg
12 mL/kg
Do not exceed a maximum cumulative dose of 12 mL/kg
New guidelines:
<70kg bolus 1.5ml/kg over 2-3mins then infusion at 0.25ml/kg/min. If patient remains unstable then repeat bolus and double infusion rate.
> 70kg bolus 100ml over 2-3mins then infuse 250ml over 15-20mins. If patient remains unstable then repeat bolus and double infusion rate. Max dose is still 12ml/kg. Only give if patinet has actually arrested. Consider it if no circulatory arrest. Seizure termination = midazolam.
Which parameter is most effective in assessing changes in volume status in children
a. Urine output
b. Change in weight
Change in weight
RCH IV fluids
“Repeated weights are the best measure of fluid status. Also document intake/inputs and ongoing losses (including urine output), with at least 12 hourly subtotals”
Minimum current for VF macroshock
100mA for macroshock.
0.1mA for microshock.
Image of an abnormal capnogram trace
a) ETT cuff leak
b) Gas analyser partial disconnection (air sampling leak)
c) Endobronchial
d) Spont breathing during PPV
Gas analyser partial disconnection (air sampling leak)
Cause: Air leak- loose connection between sampling tube and capnograph/broken connection or filter
Evidence: Upsloping of CO2 at the end of expiatory plateau & waveform returns to baseline
In a CICO how long do you pause post jet ventilation breath?
a. 10 seconds
b. 30 seconds
c. 6 seconds
d. 15 seconds
SpO2 dropped by 5% OR
30 seconds (if no reading)
“We recommend not jetting again until the SpO2 has dropped by 5% from the maximum achieved with the initial jet. The subsequent jet should be of 2 secs duration. This has been shown in the Wet Lab to be a safe and effective method. If there is no saturation reading insufflate 500 mls every 30 seconds.”
RACP endorsed jet oxygenation
Accept BSL >10 in all of the followign EXCEPT:
Diabetes ANZCA document which don’t require a higher control of BSL 10 +/- 2.5
a) Autonomic dysreflexia
b) Elderly
c) Pregnancy
d) Hypo unawareness
e) Peipheral neuropathy
f) Emergency laparotomy with poor control at baseline
Blood glucose target is 7.5 ± 2.5 mmol/l except for:
- Pregnancy: 5.0 ± 1.0 mmol/L
- Higher target (10.0±2.5 mmol/L):
- Emergency surgery with poor glycaemic control
- Known hypoglycaemia unawareness
- Known prolonged QT interval or autonomic neuropathy
- Elderly patients (>75 yrs)
https://www.diabetessociety.com.au/guideline/ads-anzca-perioperative-diabetes-and-hyperglycaemia-guidelines-adults-november-2022/
Which drug does not increase defibrillation threshold?
a. Lignocaine
b. Diltiazem
c. Sotalol
Sotalol the answer - “LOL defib”
Sotalol - decreases threshold
Amiodarone - can decrease or increase if acute or chronic Tx respectively
Lignocaine - increases threshold
2018 Journal
Sodium channel blocks increase energy needed.
Potassium and B-blockers decrease energy needed.