7.1 - Vasculitis

Question 1

is temporal arteritis granulomatous or necrotizing?

Answer 1

granulomatous

Question 2

biopsy of temporal arteritis reveals inflamed vessel wall with giant cells and fibrosis of which layer?

Answer 2

intima

Question 3

what is the treatment for giant cell arteritis? what is the consequence of no treatment?

Answer 3

• corticosteroids

- blindness

Question 4

is takayasu arteritis granulomatous or necrotizing?

Answer 4

granulomatous

Question 5

• visual and neuro symptoms
• weak or absent pulse
• elevated ESR

diagnosis? treatment?

Answer 5

• takayasu arteritis

- corticosteroids

Question 6

is polyarteritis nodosa granulomatous or necrotizing?

Answer 6

necrotizing

Question 7

which organ is spared in polyarteritis nodosa?

Answer 7

lungs

Question 8

• HTN
• abdominal pain with melena
• neuro disturbances
• skin lesions

diagnosis? treatment?

Answer 8

• polyarteritis nodosa

- corticosteroids and cyclophosphamide

Question 9

what serum marker is frequently seen with polyarteritis nodosa?

Answer 9

serum HBsAg

Question 10

• lesions at various stages
• transmural inflammation with fibrinoid necrosis
• string of pearls appearance on imaging

Answer 10

polyarteritis nodosa

Question 11

• fever
• conjunctivitis
• erythematous rash of palms and soles
• enlarged cervical nodes

Answer 11

kawasaki disease

Question 12

coronary artery involvement in kawasaki disease leads to increased risk of what two outcomes?

Answer 12

1. aneurysm with rupture

2. thrombosis with myocardial infarction

Question 13

what is the treatment for kawasaki disease?

Answer 13

• aspirin

- IVIG

Question 14

is buerger disease necrotizing or granulomatous?

Answer 14

necrotizing

Question 15

necrotizing granulomatous vasculitis involving nasopharynx, lungs, and kidneys

Answer 15

wegener granulomatosis

Question 16

• middle aged male
• sinusitis / nasopharyngeal ulceration
• hemoptysis with bilateral nodular lung infiltrates
• hematuria
• rapidly progressing glomerulonephritis

Answer 16

wegener granulomatosis

Question 17

is wegener granulomatosis positive for c-ANCA or p-ANCA?

Answer 17

c-ANCA

Question 18

what is the treatment for wegener granulomatosis?

Answer 18

cylcophosphamide and steroids

Question 19

is wegener granulomatosis granulomatous or necrotizing?

Answer 19

necrotizing and granulomatous

Question 20

what makes microscopic polyangiitis different from wegener granulomatosis?

Answer 20

microscopic polyangiitis does NOT have nasopharyngeal involvement (nor does it have granulomas)

Question 21

is microscopic polyangiitis granulomatous or necrotizing?

Answer 21

necrotizing

Question 22

is microscopic polyangiitis positive for c-ANCA or p-ANCA?

Answer 22

p-ANCA

Question 23

• asthma
• peripheral eosinophilia
• p-ANCA positive

Answer 23

churg strauss

Question 24

is churg strauss granulomatous or necrotizing?

Answer 24

necrotizing and granulomatous (with eosinophils)

Question 25

is churg strauss positive for c-ANCA or p-ANCA?

Answer 25

p-ANCA

Question 26

henoch schonlein purpura is a vasculitis due to immune complex deposition of Ig___

Answer 26

IgA

Question 27

- palpable purpura on buttocks and legs - GI pain and bleeding - hematuria (IgA nephropathy)

Answer 27

henoch schonlein purpura