What are the four phases of the cell cycle?
G1, S, G2, and M phase.
What are the two main functions of cell division?
Growth, maintenance, and repair in multicellular organisms; reproduction in single-celled organisms.
What are the stages of mitosis?
Prophase, Prometaphase, Metaphase, Anaphase, and Telophase.
What is the difference between somatic cells and gametes?
Somatic cells are diploid (2n) and produced by mitosis; gametes are haploid (1n) and produced by meiosis.
What is chromatin?
A complex of DNA and histone proteins that make up chromosomes.
What is a chromosome?
A single long double helix of DNA wrapped around histones containing genetic information.
What happens during the S phase?
DNA replication occurs, producing sister chromatids.
What happens during G1 and G2 phases?
G1 is cell growth and preparation for DNA replication; G2 prepares the cell for mitosis.
What is cytokinesis?
Division of the cytoplasm to form two daughter cells.
What is the M phase-promoting factor (MPF)?
A regulatory complex made of cyclin and Cdk that triggers mitosis.
What are the main checkpoints in the cell cycle?
G1, G2, and two M-phase checkpoints.
What happens if checkpoints fail?
Cells may divide uncontrollably, leading to cancer.
What is a proto-oncogene?
A normal gene that promotes cell division; when mutated, it becomes an oncogene.
What is a tumor suppressor gene?
A gene that prevents uncontrolled cell division; when defective, cancer can result.
What protein regulates the G1 checkpoint?
The Rb protein, which controls the E2F transcription factor.
What does the p53 protein do?
It detects DNA damage and can pause the cell cycle or initiate apoptosis.
What is binary fission?
A process in which prokaryotes replicate and divide without mitosis.
What happens during anaphase?
Sister chromatids separate and move to opposite poles.
What happens during metaphase?
Chromosomes align at the metaphase plate.
What happens during telophase?
Nuclear envelopes reform and chromosomes decondense.