Bohr Effect
CO2/O2 movement
Left OHS Curve
Right OHS Curve
What does 2-3 DPG do?
Breaks off O2 from hemoglobin
3 Primary Buffer Systems
Carbonic Acid Bicarb buffer system
Respiratory
Renal System
CO2 to ph changes
CO2 of 10 equates to 0.08 of pH in the opposite direction
Secondary Buffering System
Protein Buffering System
Phosphate Buffer System
K and pH
0.1 pH, changes K by 0.6 in opposite direction
DPG in Blood Banks
Low 2-3 DPG
PaO2
80-100
BE
-2 to 2
What causes methemoglobinemia
Nitrates
Sulfonamide
Topical caines
Exhaust
Herb/Pesticides
Nitrobenzene
10 of HCO3 change
ph 0.15 in the same direction
Bicarb replacement formula
kg/4 x BE = mEq
Bicarb Gap
Na-Cl-39
Bicarb Gap Numbers
> 6 met alkalosis
<6 hyperchloremic acidosis
First treatment for the tx of hyperkalemia
CaCl
A-a difference for shunt
> 20
A-a should not be greater than X at an FiO2 of X
120;1.0
Anion Gap Formulas and Trigger
(Na+K) - (Cl+HCO3)
>20 met acid