Addiciton

Question 1

what are some signs of drug dependence?

Answer 1

increasing tolerance
physiological withdrawal state on cessation
use of drug to avoid withdrawl
strong desire/compulsion to use
progressive neglect of other interests
keeps using despite awareness of damage

Question 2

what is the neuroscience behind dependence?

Answer 2

increased dopamine activity in mesolimbic system causes dependence

Question 3

what are the 4 L’s

Answer 3

liver
love
livelihood
law

Question 4

deaths from dependence caused by?

Answer 4

accidents/injury
liver disease
cardiovascular disease
cancers

Question 5

what is the first phase of paracetamol overdose?

Answer 5

occurs in 24 hours after ingestion

pallor, malaise, vomitting, sweating

Question 6

what is the toxic dose of paracetamol?

Answer 6

> 10g in 24 hours
or
150mg/kg

Question 7

what is the at risk of toxicity dose?

Answer 7

> 7g in 24 hours
or
75mg/kg