Methylation of a compound makes it ______
Less polar
What part of the hypothalamus is responsible for sympathetic system
Posterolateral part
What part of the hypothalamus is responsible for the parasympathetic system
Anteromedial part
Most low molecular weight neurotransmitters are synthesized in____
The nerve endings
What are cathecolamines
They are benzene ring with 3&4 hydroxylation and an Amino group
Examples of cathecolamines
Dopamine
Isoproterenol
Norepinephrine
Epinephrine
List the sympatholytic drugs which acts on the nerve endings
Methy-tyrosine- structural analogue of tyrosine which binds to tyrosine hydroxylase this blocking cathecolamine synthesis
RESERPINE- it blocks the vesicular transport mechanism
(It leads to depression)
GUANETHIDINE- prevents vessicles from fusing with the membrane this preventing the release of neurotransmitters
Alpha-methy dopa-
This is a pseudo molecule which gets converted to alpha methyl dopamine by dopamine decaboxylase
List non selective alpha blockers
Phenoxylbenzene- irreversible blocker
phentolamine - reversible blocker
Alpha 1 blockers include
Prazosin - has longer duration of action
Terazosin
Doxazosin
Tamulosin
Non selective beta blockers include
( 1st generation)
Propranolol
Timolol
Nadolol
Sotalol
Pindolol ( partial agonist)
Selective beta blockers includes
(2nd generation)
Metopronol
Bisoprolol
Acebutolol( partial agonist)
Atenolol
Esmolol
Drugs which stimulate alpha 1
Phenylephrine
Midodrine
Alpha 2 stimulant drug
Clonidine
It reduces the discharge of normal norepinephrine fekm sympathetic nerve endings
Function of norepinephrine
It stimulates alpha 1 and beta 1 but does not stimulate beta 2 significantly
Function of epinephrine
Stimulates alpha 1, beta 1 and beta 2
