What is the difference between MAO-A and MAO-B?
A. MAO-A is in neurons while MAO-B is peripheral
B. One is in the cytoplasm while other is on the exterior mitochondrial membrane
C. MAO-A preferentially breaks down serotonin, epi/norepi, while MAO-B preferentially breaks down dopamine and histamine
D. MAO-A is irreversibly blocked by phenelzine while MAO-B is not
2025
What is the difference between MAO-A and MAO-B?
A. MAO-A is in neurons while MAO-B is peripheral
B. One is in the cytoplasm while other is on the exterior mitochondrial membrane
C. MAO-A preferentially breaks down serotonin, epi/norepi, while MAO-B preferentially breaks down dopamine and histamine
D. MAO-A is irreversibly blocked by phenelzine while MAO-B is not
2025
Young girl with chaotic childhood and had “attachment” issues early in development, which is explicitly mentioned. She now presents with emotional lability and aggression. What neuropeptide is most associated with this presentation?
A. Orexin
B. Oxytocin
C. Neuropeptide S
D. Neurotensin
2025
Young girl with chaotic childhood and had “attachment” issues early in development, which is explicitly mentioned. She now presents with emotional lability and aggression. What neuropeptide is most associated with this presentation?
A. Orexin
B. Oxytocin
C. Neuropeptide S
D. Neurotensin
2025
Elderly patient completed ECT, only wants pharmacotherapy. Recommendation?
A. Nortriptyline and lithium
B. Venlafaxine and mirtazapine
C. Fluoxetine and olanzapine
2025
Elderly patient completed ECT, only wants pharmacotherapy. Recommendation?
A. Nortriptyline and lithium
B. Venlafaxine and mirtazapine
C. Fluoxetine and olanzapine
2025
As per CRISM, why is SSRI not recommended in AUD?
A. Gastrointestinal side effects
B. Worsen SI
C. Worsen drinking outcomes
D. Complicated withdrawal
2025
As per CRISM, why is SSRI not recommended in AUD?
A. Gastrointestinal side effects
B. Worsen SI
C. Worsen drinking outcomes
D. Complicated withdrawal
2025
27F with bipolar I, does not want lithium and a family member had a bad reaction to
quetiapine. She is worried about weight gain. Recommendation for maintenance therapy?
A. Divalproex 500 BID
B. Abilify 15 mg od
C. Paliperidone 3 mg q hs
D. Olanzapine 10 mg
2025
27F with bipolar I, does not want lithium and a family member had a bad reaction to
quetiapine. She is worried about weight gain. Recommendation for maintenance therapy?
A. Divalproex 500 BID
B. Abilify 15 mg od
C. Paliperidone 3 mg q hs
D. Olanzapine 10 mg
2025
Bipolar lady previously stabilized on Li (clearly says mania history). Failed quetiapine before. Stops lithium b/c of weight gain?. Now presents with MDE, meeting many of SIGECAPS (?mixed features?). Pt wants new medication and is teary eyed in office. What is the recommendation for the “acute” and “maintenance” monotherapy at present?
A. Lurasidone
B. Divalproex
C. Lamotrigine
D. Olanzapine
2025
Bipolar lady previously stabilized on Li (clearly says mania history). Failed quetiapine before. Stops lithium b/c of weight gain?. Now presents with MDE, meeting many of SIGECAPS (?mixed features?). Pt wants new medication and is teary eyed in office. What is the recommendation for the “acute” and “maintenance” monotherapy at present?
A. Lurasidone
B. Divalproex
C. Lamotrigine
D. Olanzapine
2025
15M brought to the ED by friends, he is agitated and bizarre. Friend admits he was huffing industrial paint substance in his garage later on. He is put in a room and starts banging on the walls (he is clearly alert and agitated). What do you administer to sedate him?
A. Lorazepam IM
B. Olanzapine IM
C. Diphenhydramine IM
D. Haldol IM
2025
15M brought to the ED by friends, he is agitated and bizarre. Friend admits he was huffing industrial paint substance in his garage later on. He is put in a room and starts banging on the walls (he is clearly alert and agitated). What do you administer to sedate him?
A. Lorazepam IM
B. Olanzapine IM
C. Diphenhydramine IM
D. Haldol IM
2025
ADHD patient who showed good but partial response to stimulant, what is 1st line augmentation “assuming no contraindications”?
A. Atomoxetine
B. Guanfacine ER
C. Bupropion
D. TCA
2025
ADHD patient who showed good but partial response to stimulant, what is 1st line augmentation “assuming no contraindications”?
A. Atomoxetine
B. Guanfacine ER
C. Bupropion
D. TCA
2025
Lady on venlafaxine finds out she is 10 weeks pregnant. Good response to venlafaxine.
She wants to stay on venlafaxine. What is your recommendation?
A. Cross taper to sertraline
B. Continue venlafaxine
C. Stop venlafaxine and start CBT
2025
Lady on venlafaxine finds out she is 10 weeks pregnant. Good response to venlafaxine.
She wants to stay on venlafaxine. What is your recommendation?
A. Cross taper to sertraline
B. Continue venlafaxine
C. Stop venlafaxine and start CBT
2025
Female 74 year old professor who is retired and with dementia. She is on donepezil 5 mg x 2mo and has developed persistent nausea that won’t go away. She is clearly and explicitly intent on wanting to continue with a Chol-i. What is the best option?
A. Switch to galantamine
B. Switch to memantine
C. Add ondansetron
D. Add Gravol
2025
Female 74 year old professor who is retired and with dementia. She is on donepezil 5 mg x 2mo and has developed persistent nausea that won’t go away. She is clearly and explicitly intent on wanting to continue with a Chol-i. What is the best option?
A. Switch to galantamine
B. Switch to memantine
C. Add ondansetron
D. Add Gravol
2025
9M (kid) is presenting with psychosis. Has long face, small chin/mouth/ears
A. Fragile X
B. XXY
C. 22q11.2
2025
9M (kid) is presenting with psychosis. Has long face, small chin/mouth/ears
A. Fragile X
B. XXY
C. 22q11.2
2025
Male is agitated and presenting to the ED. Threatening to slit his throat because he was not getting double portions for meals. When you shake his hand, you are surprised by his hypotonia. He has IDD, is small and obese. What is the diagnosis?
A. Prader-Willi
B. Fragile X
2025
Male is agitated and presenting to the ED. Threatening to slit his throat because he was not getting double portions for meals. When you shake his hand, you are surprised by his hypotonia. He has IDD, is small and obese. What is the diagnosis?
A. Prader-Willi
B. Fragile X
2025
58F with bipolar stable on Li (serum 0.8) and gabapentin for 15yr, now has some
parkinsonism features. She has a soft, muffled voice. Bilateral resting tremor. No facial
expressions. Difficulty getting out of the chair. Not making good eye contact. Autonomic
symptoms.
A. Reduce lithium
B. Start levodopa
C. Reduce gabapentin
D. Benztropine
2025
58F with bipolar stable on Li (serum 0.8) and gabapentin for 15yr, now has some
parkinsonism features. She has a soft, muffled voice. Bilateral resting tremor. No facial
expressions. Difficulty getting out of the chair. Not making good eye contact. Autonomic
symptoms.
A. Reduce lithium
B. Start levodopa
C. Reduce gabapentin
D. Benztropine
2025
83M in LTC with longstanding bipolar stable on divalproex (level 450) and clonazepam. Now MANIC (explicitly says he is manic in the first or second sentence). He is trying to use the computer at the nursing home to buy an expensive gold ring. Not bothering anyone at LTC, in fact they are enjoying his antics. What is the best first step?
A. Admit
B. Increase divalproex
C. Add risperidone
D. Decrease clonazepam
2025
83M in LTC with longstanding bipolar stable on divalproex (level 450) and clonazepam. Now MANIC (explicitly says he is manic in the first or second sentence). He is trying to use the computer at the nursing home to buy an expensive gold ring. Not bothering anyone at LTC, in fact they are enjoying his antics. What is the best first step?
A. Admit
B. Increase divalproex
C. Add risperidone
D. Decrease clonazepam
2025
37M, steals cars and social security in order to not miss bill payments, no remorse for stealing cars, impulsive, behaviours started after 15 as confirmed by mom (aka NO conduct history as a kid), no mania/psychosis/depression, no hx of manipulation or aggression. What is the dx?
A. Conduct disorder
B. ASPD
C. Kleptomania
D. Adult antisocial behaviour
2025
37M, steals cars and social security in order to not miss bill payments, no remorse for stealing cars, impulsive, behaviours started after 15 as confirmed by mom (aka NO conduct history as a kid), no mania/psychosis/depression, no hx of manipulation or aggression. What is the dx?
A. Conduct disorder
B. ASPD
C. Kleptomania
D. Adult antisocial behaviour
2025
How does mirtazapine exert serotonergic activity?
A. 5HT2A/C antagonism
B. SERT
C. MAOI
D. Inhibits presynaptic alpha2 receptors
2025
How does mirtazapine exert serotonergic activity?
A. 5HT2A/C antagonism
B. SERT
C. MAOI
D. Inhibits presynaptic alpha2 receptors
2025
DID patient, what is the “goal of therapy” with this patient?
A. Integrate the personalities
B. Build up one personality
C. Remove harmful personality
D. Attain the most functional personality (aka “resolution”, which is “incomplete
merging” of the identities but that which is satisfactory to the patient)
2025
DID patient, what is the “goal of therapy” with this patient?
A. Integrate the personalities
B. Build up one personality
C. Remove harmful personality
D. Attain the most functional personality (aka “resolution”, which is “incomplete
merging” of the identities but that which is satisfactory to the patient)
2025
Theory that says the therapist is going to provide the empathy and narcissistic needs that this person didn’t get when they were younger in patient with NPD.
A. Kohut
B. Kernberg
C. Winnicott
D. Guntrip
2025
Theory that says the therapist is going to provide the empathy and narcissistic needs that this person didn’t get when they were younger in patient with NPD.
A. Kohut
B. Kernberg
C. Winnicott
D. Guntrip
2025
16F with AN admitted for refeeding syndrome, which antidepressant is contraindicated?
A. Bupropion
B. Sertraline
C. Fluoxetine
2025
16F with AN admitted for refeeding syndrome, which antidepressant is contraindicated?
A. Bupropion
B. Sertraline
C. Fluoxetine
2025
A young adult male jumped and injured their head and developed an intracranial hemorrhage. He is explicitly noted to have been intelligent, nice, etc (really selling his peak executive functioning). The injury was noted to be in the left DLPFC. What should you be really concerned about in this guy?
A. Hypersexuality
B. Impulsiveness
C. Apathy and avolition
D. Executive dysfunction
2025
A young adult male jumped and injured their head and developed an intracranial hemorrhage. He is explicitly noted to have been intelligent, nice, etc (really selling his peak executive functioning). The injury was noted to be in the left DLPFC. What should you be really concerned about in this guy?
A. Hypersexuality
B. Impulsiveness
C. Apathy and avolition
D. Executive dysfunction
2025
Patient is on clozapine for 1 year, and recently switched from smoking to vaping. He drinks 3 to 5 shots of whiskey a day. Now he is more sedated and is drooling. What caused this change?
A. Switching to vaping
B. Infection, due to neutropenia
C. Alcohol withdrawal
D. Smoking more cannabis
2025
Patient is on clozapine for 1 year, and recently switched from smoking to vaping. He drinks 3 to 5 shots of whiskey a day. Now he is more sedated and is drooling. What caused this change?
A. Switching to vaping
B. Infection, due to neutropenia
C. Alcohol withdrawal
D. Smoking more cannabis
2025
Psychedelic that acts as a weak MAOI and with which caution should be exercised when added to an antidepressant in particular?
A. LSD
B. Mescaline
C. Psilocybin
D. Ayahuasca (aka DMT, Huasca, yagé, Kamarampi, Huni, brew, daime, the tea, la purga, aka tree bark, aka toad juice, aka the spirit molecule, the most potent psychedelic known to man, aka GOD)
2025
Psychedelic that acts as a weak MAOI and with which caution should be exercised when added to an antidepressant in particular?
A. LSD
B. Mescaline
C. Psilocybin
D. Ayahuasca (aka DMT, Huasca, yagé, Kamarampi, Huni, brew, daime, the tea, la purga, aka tree bark, aka toad juice, aka the spirit molecule, the most potent psychedelic known to man, aka GOD)
2025
Psychotic patient started on clozapine 2 weeks ago, now has fever 38.3, tachycardic, hypertensive, complaining about substernal pain in a psychotic way. CBC normal, no mention of rigidity. What abnormality do you expect first in investigations?
A. Creatinine
B. CRP
C. ST elevation
D. LFTs
2025
Psychotic patient started on clozapine 2 weeks ago, now has fever 38.3, tachycardic, hypertensive, complaining about substernal pain in a psychotic way. CBC normal, no mention of rigidity. What abnormality do you expect first in investigations?
A. Creatinine
B. CRP
C. ST elevation
D. LFTs
2025
Psychotic pt with vertical movements of mouth with no tongue protrusion (i.e. rabbit syndrome symptoms) but otherwise stable, recommendation?
A. Benztropine
B. Clonazepam
C. Reduce antipsychotic
D. Propranolol
2025
Psychotic pt with vertical movements of mouth with no tongue protrusion (i.e. rabbit syndrome symptoms) but otherwise stable, recommendation?
A. Benztropine
B. Clonazepam
C. Reduce antipsychotic
D. Propranolol
2025