Medication Information

Question 1

MOA of ketamine

Answer 1

-Antidepressant MOA is unclear
-Leading hypothesis is ANTAGONISM of NMDA receptors on GABAergic neurons in the prefrontal cortex
–>Leads to disinhibition and a molecular and cellular cascade
–>Leading to a burst of glutamate and sustained synaptogenesis in depression-related neuronal circuits, dependent on an increase in brain-derived neurotrophic factor and protein synthesis

Question 2

Ketamine metabolized by?

Answer 2

-3A4
-2D6
-2C19
-2B6
-2A6