Alpha blockers

Question 1

What are the generic and brand names of alpha blockers?

Answer 1

• Doxazosin (Cardozin)

* Tamsulosin (Flomax)

Question 2

What is the method of action of alpha blockers?

Answer 2

• Most are highly selective for α-adrenoceptor
• α-adrenoceptor are found in smooth muscle
• Blocking receptors causes vasodilation and ↓ resistance to bladder outflow

Question 3

What are the indications for alpha blockers?

Answer 3

• First line for improvement of BHP

* Add on treatment in resistant hypertension

Question 4

What are the contraindications for alpha blockers?

Answer 4

• Postural hypotension

Question 5

What are the side effects of alpha blockers?

Answer 5

• Postural hypotension
• Dizziness
• Syncope

Question 6

What drugs interact with alpha blockers?

Answer 6

• Antihypertensives – be cautious of dropping the blood pressure too much

Question 7

What organ eliminates alpha blockers?

Answer 7

Kidney

Question 8

What information should be given to a patient taking alpha blockers?

Answer 8

• Best to be taken at bedtime