Angina

Question 1

What is MOA of nitrates?

Answer 1

-NO causes vasodilation by activating guanylyl cyclase which then activates cGMP which form myosin LC-vasodilation

Question 2

T/F Nitroglycerin is used in acute HF or angina

Answer 2

TRUE

Question 3

What are some adverse effects of nitrates (2)?

Answer 3

• hypotension

- reflex tachycardia

Question 4

What are the applications of Nitrates(3)?

Answer 4

• prophylaxis
• ACS
• Angina

Question 5

What are ADE with nitrates?(3)

Answer 5

• tachycardia
• headache
• orthostatic hypotension

Question 6

What is the clinical application of transdermal nitroglycerin?

Answer 6

• prophylaxis oral and trans dermal
• IV used in ACS
• sublingual used in acute episodes of angina

Question 7

What are the bad effects of nitrates?

Answer 7

• decreased diastolic filling
• reflex tachycardia
• increase in contractility

Question 8

Name the 5 drugs used to treat angina?

Answer 8

• CCB
• BB
• nitrates
• Ranolazine
• Ivabradine

Question 9

What is MOA of Ranolazine?

Answer 9

blocks NA channels in heart to reduce oxygen demands in heart

Question 10

What are ADE of Ranolazine?

Answer 10

QT prolongation

Question 11

What are the clinical uses of Ranolazine?

Answer 11

• prophylaxis for stable angina

- increases exercise capacity when added to other anti-anginal therapies?