ANS functions
-regulate homeostasis
-co-ordinate response to exercise and stress
-assists endocrine sys to regulate reproduction
-regulate function of involuntary organs
enteric nervous sys
often classified as a subdivision of autonomic efferent nervous system
adjustments during exercise (fight or flight)
-inc heart rate and blood pressure
-blood flow shunted to skeletal muscle and heart
-bronchioles dilate
-liver releases glucose
autonomic tone
-balance between sympathetic and parasympathetic actiavtion
-regulated by hypothalamus
-(most visceral organs both symp and parasymp innervated)
where so sympathetic (fibres) neurons leave the CNS
-thoracic region
-lumbar region
-> of the spinal cord
where do parasymp (fibres) neurons leave the CNS
-brainstem
-sacral portion
-> of spinal cord
where are NTs stored
in pre-synaptic neuron
where is the receptor for the NT
on post-ganglionic neuron
length of synapses in parasymp division
-long preganglionic
-short postganglionic
length of synapses in symp division
-short pre
-long post
location of soma in parasymp (preganglionic)
-brain stem
-or sacral
location of soma in parasymp (postganglionic)
-in a ganglion near target orga n
location of soma in symp (preganglionic)
-in spine
location of soma in symp (postganglionic)
–next to spinal cord
M1,3,5
excitatory: activate phospholipase C (Gq)
M2,4
inhibatory: inhibit adneylate cyclase (Gi)
muscarinic antagonist eg
atropine (atropa belladonna)
adrenal medulla
-set of postganglionic neurons that never develop into a neuron
-secretes steroid hormones
-activation: releases 80% adrenaline and 20% noradrenaline- into blood (+small amounts dopamine, ATP, neuropeptides)
cardiac output=
stroke volume.heart rate
mean arterial resistance=
cardiac output. total peripheral resistance
following haemorrhage and reflex mechanism triggered (compared to pre-haemorrhage values):
-CO2 decrease
-total peripheral resistance increase
sympatholytic durgs
drugs that interfere with sympathetic function
parasympathomimetic drugs
drugs that enhance cholinergic effects