Antidiarrheals

Question 1

absorbents MOA

Answer 1

binds to bacteria causing diarrhea to carry them out with feces

Question 2

absorbents AEs

Answer 2

• aspirin product: use with caution in children recovering from flu/chickenpox, increased bleeding time, GI bleed, tinnitus
• Decrease effectiveness of many drugs (digoxin, hypoglycemic drugs, anticoagulants)

Question 3

absorbent drug names to know

Answer 3

• bismuth subsalicylate (Pepto-Bismol)

- attapulgite (Kaopectate)

Question 4

Intestinal flora modifiers

Answer 4

• bacterial products obtained from Lactobacillus organisms
• Normally reside in intestines to keep “bad” bacteria in check
• Help restore normal balance to suppress harmful organisms

Question 5

opiates MOA

Answer 5

• decrease GI motility and propulsion
• Slowing transit time in intestines = absorption of water and electrolytes
• Can also reduce pain

Question 6

opiate drug names to know

hint: low motility

Answer 6

• diphenoxylate (Lomotil)

- has added atrophine to prevent recreational opioid use

Question 7

opiate AEs

Answer 7

sedation, dizziness, constipation, nausea, vomiting, respiratory depression, bradycardia, hypotension, urinary retention