Antigen Recognition Flashcards by Lucas Tibbs

Q

what is the exception of MHC recognition

A

superantigens

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Q

what are B cell superantigens

A

staphlyococcal protein A; HIV

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Q

what are the T cell superantigens

A

S. aureaus, S. pyogenes

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Q

where does b cell superantigen bind

A

Fab regions

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Q

where does T cell superantigen bind

A

VB domain

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Q

what are the three signals in antigen recognition

A

antigen recognition
costimulation
differentiaion cytokines

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Q

what are the costim molecules on APC

A

CD80 and CD86

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Q

what are the costim receptors on T cells

A

CD28

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Q

what does cd28 do

A

promote T cell proliferation

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Q

what is the B cell costim

A

CD40

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Q

are antigenic but not immunogenic

A

haptens

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Q

enhance immunogenicity of antigen/immunogen

A

adjuvents

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Q

B cells primary recognize

A

polysaccharides

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