Immunogenetics

Question 1

V regions of light chains are encoded by

Answer 1

V and J

Question 2

aberrant kappa; lamda #s indicate

Answer 2

presence of malignant lymphoproliferation

Question 3

V regions of heavy chains are encoded by

Answer 3

VDJ

Question 4

what is the rule to ensure you have one V and one J saegment

Answer 4

12-23

Question 5

what is the results of not having RAG

Answer 5

B and T cells fail to develop

Question 6

recombination is completely dependent upon

Answer 6

NHEJ

Question 7

what does TDT do

Answer 7

randomly adds nucleotides

Question 8

what contributes to combinatory diversity

Answer 8

RAG and NHEJ

Question 9

what contributes to junctional diversity

Answer 9

1. exonuclease actuvuty
2. DTD activity
3. DNA pol

Question 10

process of silencing either a paternal or maternal allele

Answer 10

allelic exclusion

Question 11

what is a marker for acute lympohatic leukemia

Answer 11

high TDT activity

Question 12

whajt does Activation Induced Deaminase (AID) do

Answer 12

inserts cytosine to uracil mutations in germinal B cells

Question 13

AID is capable of switching

Answer 13

classes