TOP 300 > Antigout > Flashcards

Antigout Flashcards

(22 cards)

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1
Q

brand name

allopurinol (xanthase oxidase inhibitor)

A

zyloprim

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2
Q

indication

allopurinol (xanthase oxidase inhibitors)

A

gout, hyperuricemia, tumor lysis syndrome, kidney stones

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3
Q

MOA

allopurinol (xanthase oxidase inhibitors)

A

decrease uric acid production

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4
Q

common ADRs

allopurinol (xanthase oxidase inhibitors)

A
  • diarrhea
  • liver enzymes abnormality
  • rash
  • acute gouty arthritis
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5
Q

rare but serious ADRs

allopurinol (xanthase oxidase inhibitors)

A
  • Stevens Johnson Syndrome (SJS)
  • toxic epidermal necrolysis (TENS)
  • aplastic anemia
  • agranulocytosis
  • hepatotoxicity
  • renal failure
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6
Q

contraindications

allopurinol (xanthase oxidase inhibitors)

A

hypersensitivity, HLA-B 5801

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7
Q

key counseling points

allopurinol (xanthase oxidase inhibitors)

A
  • take after meals to alleviate GI symptoms
  • drink plenty of water to prevent kidney stones
  • avoid alcohol and caffeine
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8
Q

brand name

febuxostat (xanthase oxidase inhibitor)

A

uloric

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9
Q

indication

febuxostat (xanthase oxidase inhibitor)

A

hyperuricemia

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10
Q

MOA

febuxostat (xanthase oxidase inhibitor)

A

decrease uric acid production

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11
Q

common ADRs

febuxostat (xanthase oxidase inhibitor)

A
  • diarrhea
  • nausea
  • acute gouty arthritis
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12
Q

rare but serious ADRs

febuxostat (xanthase oxidase inhibitor)

A
  • ECG abnormalities
  • stroke
  • mood changes
  • rash
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13
Q

contraindications

febuxostat (xanthase oxidase inhibitor)

A

concurrent use of azathioprine and 6-mercaptopurine

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14
Q

black box warning

febuxostat (xanthase oxidase inhibitor)

A

increased risk of death (cardiac, all-cause)

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15
Q

key counseling points

febuxostat (xanthase oxidase inhibitor)

A
  • take with food
  • seek medical attention for severe mood swings, rashes or abnormal heartbeat
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16
Q

brand name

colchicine (antigout agent)

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A

colcrys, gloperba, mitigare

17
Q

indication

colchicine (antigout agent)

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A

gout, familial mediterranean fever

18
Q

MOA

colchicine (antigout agent)

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A

Unknown, may interferes with crystal
deposition in joint tissues and may inhibit locomotion and chemotaxis of neutrophils

19
Q

common ADRs

colchicine (antigout agent)

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A
  • diarrhea
  • nausea
20
Q

rare but serious ADRs

colchicine (antigout agent)

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A
  • agranulocytosis
  • rhabdomyolysis (esp. w/ lipid lower agent)
21
Q

contraindications

colchicine (antigout agent)

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A

use w/ strong CYP3A4/5 inhibitors in patients w/ renal or hepatic failure

22
Q

key counseling points

colchicine (antigout agent)

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A
  • Take as instructed, dosing for acute and chronic gout are different.
  • Dose dosing to symptom relief or onset of adverse effects, particularly diarrhea
  • This drug may interact with your other medication
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