Antiparistics

Question 1

Melarsoprol

Answer 1

• Binds to inhibit parasitic enzymes of sulfhydryl group

- Later staves of CNS involvement

Question 2

Leishmaniasis

Answer 2

• Sodium stibogluconate -> Mech unknown

- Miltefosine -> Bind to parasitic DNA/inhibits CytC

Question 3

Giardiasis

Answer 3

Metronidazole: Binds flaggella

Tinidazole: Disrupts DNA tertiary structure + NA synthesis

Quinacrine: Binds membranephosphlipis * Crosses Placenta

Nitazoxanide: Synthetic antiprotozoal

Question 4

Trichomoniasis

Answer 4

Metronidazole

Tinidazole

**These drugs also treat Anaeroic bacterial infections

Question 5

Luminal Amebicides

Answer 5

Iodoquinol

Paromomycin

Tinidazole/metronidazole

Question 6

Paromomycin

Answer 6

• Intestinal amoebas

*** First Line for Amebiasis + Giardiasis in Pregnancy

Question 7

Systemic Amebicides

Answer 7

Emetine + Dehydroemetine

*Contra in pregnancy and can cause Cardiotoxicity

Question 8

Toxoplasmosis

Answer 8

Pyrimethamine + Sulfonamides

Atovaquone

Question 9

Pneumocystosis

Answer 9

• TMP-SMZ
• Pentamidine
• Atovaquone
• Dapsone
• Eflornithine (IV)
• PRimaquine + Clindamycin

Question 10

Antimalarial

Answer 10

Erythrocyte:

• Proguanil
• Pyrimethamine

Exoerythrocytic:

• Prophylactic: Proguanil + Pyrimethamine
• Primaquine
• Chloroquine + Quinine

Other:

• Mefloquine -> Resistant to Chloroquine
• Tafennoquine -> Single dose radical cure
• Malarone: Atovaquone + Proguanil
• CoArtem: Artemther + Lumefantrine -> Chinese Herb + LA Antimalarial

Question 11

Common Antiprotozoal Adverse affects

Answer 11

• Embrytoxic
• GI disturbance
• Nausea
• Anorexia
• Voiting
• Dizziness
• Tinnitus
• Fatigue

Question 12

Nematodes

Answer 12

• Mebendazole + Albendazole
• Pyrantel Pamoate
• Ivermectin

Question 13

Wucheria Bancrofti

Answer 13

• Tissue Nematode —> Filariasis (tropical eosinophilia) + Elephantiasis; Hydrocele Testicles
• Treat: Diethylcarbamzine, Ivermectin, Albendazole

Question 14

Niclosamide

Answer 14

• Used for Cestodes (Taenia)

- Use with Laxative for Ova

Question 15

Praziquantel

Answer 15

• Trematodes (flukes) + Cestodes

- Schistosoma + Taenia