Introduction

Question 1

Three Types of Pharmacology

Answer 1

Pharmacodynamics –> What it does to body
Pharmacokinetics –> What Body does to drugs
Pharmacogenomics –> Influence of genetic variation on drug responses in patients

Question 2

What four factors are considered to optimize drug therapies?

Answer 2

Absorption
Distribution
Metabolism
Elimination

Question 3

The use of Trastuzumab is an example of?

Answer 3

Pharmacogenomics –> HER2 testing for breast Cancer

Question 4

What three Federal legislations are important for drug therapies?

Answer 4

Food, Drug, Cosmetics Act: Gives FDA oversight of drug safety
Comprehensive Drug Abuse Prevention and Control Act: Security and Record Keeping of Drugs
Dietary Supplement Health and Education Act: Regulation of Labeling, Production, and claims regarding supplements

Question 5

What assumption is made from Fick’s Law relating to Drug diffusion in organs?

Answer 5

Drugs are absorbed faster from organs with large surface areas and thinner membranes

Question 6

Oral/Enteral Drug administration

Answer 6

Advantages: Safest, most conventioneer, and economical
Disadvantages: Must cross Digestive epithelium and vascular epithelium

Question 7

Recal Drug Administration

Answer 7

Irregular/incomplete absorption; Half will bypass liver

Question 8

Intramuscular injection

Answer 8

• Must avoid sciatic nerve in gluteal injection

Relatively short onset

Question 9

SubQ injection

Answer 9

• Inactivated by GI Tract

- Slow-released drugs via simple diffusion

Question 10

IV injection

Answer 10

• Rapid onset
• no oily solutions
• Not too fast or slow

Question 11

Intradermal Injection

Answer 11

• Very small volumes

- Diagnostic skin testing (TB)

Question 12

Intrathecal injection

Answer 12

• Subarachnoid space
• bypass BBB
• Possible bad reactions/side effects

Question 13

Inhalation administration

Answer 13

• Gaseous/volatile drugs
• VERY rapid entry
• Bypass initial hepatic metabolism