Antipsychotics

Question 1

Classify antipsychotic drugs

Answer 1

1. Phenothiazines
2. Thioxanthenes
3. Butyrophenones
4. Atypical antipsychotics
5. Others

Question 2

What is the mechanism of action of antipsychotics

Answer 2

1. Conventional antipsychotics block D2 receptors in the limbic system in meso critical areas
2. Atypical antipsychotics block 5HT2 Receptors in the mesolimbic system

Question 3

What are the actions of chlorpromazine in the CNS

Answer 3

1. Reduces agitation and aggressiveness
2. reduces spontaneous movements
3. suppresses hallucinations and delusions
4. relieves anxiety
5. corrects disturbed thought and behaviour
6. does not affect intelligence but impairs vigilance

Question 4

How does chlorpromazine affect the endocrine system

Answer 4

Blocks dopamine receptors which are prolactin inhibitory factor.

Question 5

What are the adverse effects of antipsychotics

Answer 5

1. Parkinsonism
2. acute dystonias
3. Akathisia
4. neuroleptic malignant syndrome
5. tardive dyskinesia
6. muscarinic, Alpha-1 and H1 receptor blocking
7. weight gain
8. Endocrine
9. hypersensitivity

Question 6

How do you cure drug induced parkinsonism from antipsychotics

Answer 6

Central acting anti-cholinergics

Question 7

Neuroleptic malignant syndrome caused by antipsychotic can be cured by which drug

Answer 7

IV dantrolene

Question 8

Which Antipsychotic drugs cause weight gain

Answer 8

Clozapine and olanzapine

Question 9

Which drug is a reserve a drug for antipsychotics

Answer 9

Clozapine

Question 10

Which antipsychotic drugs cause QT prolongation

Answer 10

Quetiapine
Amisulpiride

Question 11

What is the other name of adverse effects of chloropromazine

Answer 11

Extra Pyramidal symptoms

Question 12

What are the side effects of clozapine

Answer 12

1. Sedation
2. salivation
3. seizures
4. weight gain
5. hypotension
6. agranulocytosis

Question 13

What are the side effects of olanzapine

Answer 13

1. Dry mouth
2. constipation
3. weight gain
4. rarely EPS

Question 14

Which drug is used if there is resistant cases of schizophrenia

Answer 14

Clozapine

Question 15

Which drug is useful for the prevention and treatment of nausea and vomiting associated with migraine or emesis to the anti-cancer drugs

Answer 15

Prochlorperazine

Question 16

Which drugs treat hiccoughs

Answer 16

chlorpromazine

Question 17

What are other therapeutic uses of antipsychotics

Answer 17

1. Schizophrenia
2. mania (can be used in bipolar disorder)
3. an anti-emetic
4. intractable hiccough

Question 18

Name phenothiazines

Answer 18

1. chlorpromazine
2. Triflupromazine
3. Trifluperazine
4. Thioridazine
5. Fluphenazine

Question 19

Name thioxanthene drugs

Answer 19

Thiothixene

Question 20

Name butyrophenone drugs

Answer 20

1. Haloperidol
2. Trufluperidol

Question 21

Name atypical antipsychotics

Answer 21

1. Resperidone
2. Clozipine
3. Olanzapine
4. zotepine
5. aripiprazole
6. ziprasidone
7. Amisulpiride
8. Quetuapine
9. Zotepine

Question 22

Name other drugs used as an antipsychotic agent

Answer 22

1. Loxapine
2. Pimozide

Question 23

Which drugs can elevate lithium levels in the blood

Answer 23

1. Loop diuretics
2. NSAIDs
3. angiotensin converting enzyme inhibitors (ACEIs)
4. Thiazides
5. dehydration (condition)

Question 24

Which drugs increase renal clearance of lithium

Answer 24

Caffeine
Theophylline

Question 25

What other drugs can be used for bipolar disorder

Answer 25

1. Anti-convulsions 2. antipsychotics 3. Benzodiazepines 4. Valporic acid

Question 26

What are the adverse effects of lithium

Answer 26

1. Tremor, sedation, ataxia, aphasia 2. thyroid enlargement 3. Edema 4. acneiform skin 5. leucocytosis 6. nephrogenic diabetes insipidus

Question 27

Which drug may cause congenital cardiac anomalies if taken in pregnancy

Answer 27

Lithium

Question 28

Which type of phenothiazine Causes the toxic effect of retinal pigmentation

Answer 28

Thioridazine

Question 29

Which drug may cause ocular disfunction

Answer 29

Thioridazine

Question 30

What are the toxic effects of thioridazine

Answer 30

1. Ocular dysfunction 2. Conduction defects in the heart and can cause fatal ventricular arrhythmias