Antipsychotics

Question 1

Mechanism of action (SGA)

Answer 1

RISPERIDONE is a newer atypical/second generation neuroleptic and is more selective than the older typical neuroleptics.

Question 2

Risperidone can bind to..?

Answer 2

dopamine D2, 5-HT2, and a” adrenergic receptors in the brain

Question 3

Atypical neuroleptics

Answer 3

which have little or noe affinity for D1 receptors, do not exhibit some of the side effects associated with D1 antagonism that the older neuroleptics have.

Question 4

Main indications

Answer 4

psychotic states
bipolar disorder
Violent behavior

(de er fremhevet i rødt i pwerpointen)

Question 5

Treatment guideline (acute treatment)

Answer 5

• Often higher doses
• Multiple doses administrer daily
• Couple of weeks
• mono therapy vs polytherapy

Question 6

Treatment guideline (maintenance treatment)

Answer 6

• usually lower dose
• can last for years
• once daily administration
• often monotherapy

Question 7

Treatment guideline (long acting depot medication)

Answer 7

• improves adherence to treatment