Ligand
A signal molecule that binds to a plasma membrane protein
What is a G protein coupled receptor?
A specific type of membrane receptor protein
How does a G protein coupled receptors work? Structure/function
What is a protein phosphatase
enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein ( how the process is reversible- started by protein kinases)
What is a protein kinase
enzyme that selectively modifies other proteins by covalently adding phosphates to them (phosphorylation)
What is cAMP
a second messenger(like CA+), or cellular signal occurring within cells, that is important in many biological processes (used for intracellular transduction)– BIND TO G PROTEINS IN CELL
What do second messengers do?
Relay message from the inside of the membrane throughout the cytoplasm
What is the function of the second messenger 1P3
Bind to and open ligand gated channels
What is a ligand gated ion channel and how does it work?
transmembrane channel protein that uses a ligand (like a neurotransmitter) to let ions through
G-protein pathways are involved in many…..
human medicines for diseases
Signal amplification is most often achieved by
an enzyme cascade
What does a protein kinase do?
transfers phosphates from ATP to proteins
What does a protein phosphatase do?
Removes phosphates
What is a phosphorylation cascade?
when enzymes called kinases phosphorylate a series of molecules, or get a phosphate group added to them, which they can use in cellular processes (reversible)
Do plant cells communicate using hormones?
yes
What converts cAMP to AMP
phophodiesterase
Which of the following is a chemical message that usually travels through the bloodstream to target cells?
hormone
4 basic types of cell signaling
paracrine signaling =
NEARBY affects target cells close to the cell from which it was secreted
endocrine =
DISTANT messenger system when hormones are released by internal glands directly into the circulatory system and that target and regulate distant organs
autocrine =
ME MYSELF AND I when a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell
Simple nerve reflexes use signaling molecules called
neurotransmitters
In the signal transduction mechanism known as protein phosphorylation
the signaling molecule binds to a surface receptor, the receptor kinases play a key role in triggering the signal cascade, and the phosphorylated proteins act with enzymes to trigger the signal cascade.
Cell signaling involves converting extracellular signals to specific responses inside the target cell. How does a cell initially respond to a signal.
The cell experiences a change in receptor conformation