Autoimmune Conditions

Question 1

Key Features of Wegener’s Granulomatosis

Answer 1

1. Small to medium vessel polyangiitis
2. Necrotising
3. Lungs and upper airways: Chronic sinusitis, ulcers of nose and palate, nodules and cavities in lungs
4. Cresenteric glomerulonephritis
5. cANCA positive
6. Treated with cyclophosphamide and corticosteroids

Question 2

Key features of Churg Strauss

Answer 2

1. Eosinophilic granulomatosis
2. pANCA positive
3. Asthma
4. Sinusitis
5. Skin lesions
6. peripheral neuropathy
7. GI disease: Ulcer, bleeding, colitis, perforations, stenosis and obstructions
8. Heart disease: Cardiomyopathy, pericarditis, arrythmias
9. Kidney failure: ANCA golmerulonephritis
10. Treat with corticosteroids