Gram-negative, encapsulated, ox-positive aerobic rod
Pseudomonas
Antibiotic mechanism of inactivation
Penicillin, cephalosporin - B-lactamase Aminoglycosides, chloramphenical - inactivated by acetyl group Tetracycline - efflux pump Sulfonamide - Export Vanc - D-ala D lactate
GBS characteristics
beta-hemolysis (clear), bacitracin resistant, CAMP+
Staph virulence factor
Protein A - binds Fc of IgG inhibiting phagocytosis, complement activation
Strep pneumo virulence factor
IgA protease + capsule
Other: optochin sensitive, conjugate vaccine
Early vs late septic shock
Early - High CO, low TPR
Late - Low CO, high TPR
Cat’s PLACESS
Pseudomonas Listeria Aspergillus Candida E. Coli Staph Serratia
Anaeorbic lung abscess
Oral secretions - Bacteroides, fusobacterium, peptostretococcus
Anaerobe coverage
Metronidazole