TB

Question 1

Rifampin mechanism and side effect

Answer 1

inhibits bacterial DNA-dependent RNA polymerase.

Side effects:
GI, rash, red-orange fluid, cytopenias

Question 2

Isoniazid

Answer 2

Inhibits mycolic acid synthesis in cell wall

Side effect:
Neurotoxicity (give with vit. B6)
hepatoxic

Question 3

Pyrazinamide

Answer 3

Unclear

Hepatotoxic, hyperuricemia

Question 4

Ethambutol

Answer 4

Inhibits arabinosyl transferase polymerization of cell wall

Optic neuropathy (red-green color blindness)

Question 5

Fungus ball after TB

Answer 5

Aspergillus - broom like on silver stain