I & I Part III > Bacterial Pathogenesis > Flashcards

Bacterial Pathogenesis Flashcards

(22 cards)

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1
Q

Pathogenicity

A

The ability to cause disease in a susceptible host (plants, animals, humans)

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2
Q

Host Defenses

A
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3
Q

Beating First Line Defenses - Attachment

A

Attachment may be sufficient for disease

• Bordetella pertussis

– whooping cough

– Toxins produced

– No invasion

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4
Q

Beating First Line Defenses - - Invasion

A

Submucosa

  • Local spread
  • Bacteremia
  • Metastatic spread
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5
Q

Beating Second Line Defenses

A
  • Metabolism – nutrients, siderophores (Fe+++)
  • Extracellular

– Phagocytes

– Complement

– Toll-like receptors (TLRs)

– molecular patterns (LPS)

– Adaptive immune system

  • Intracellular – killing mechanisms of professional phagocytes
  • Capsules
  • Antiphagocytic
  • Alternate pathway C3b – Serum factor H binding
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6
Q

Beating Second Line Defenses - Capsules

A
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7
Q

Beating Second Line Defenses - Adaptive Immunity

A
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8
Q

Beating Second Line Defenses - Extracellular Mechanisms

A
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9
Q

Beating Second Line Defenses - Phagosomal Replication

A
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10
Q

Beating Second Line Defenses - Resistance to Intracellular Killing

A
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11
Q

Beyond finding a site to replicate what is another benefit (for the pathogen) of an intracellular strategy?

A

Evade Th2 response

TH2 – is for extracellular (Antibodies/eosinophils) TH1 – is for intracellular (CD8 cytotoxic T-cells)

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12
Q

Injury

A

Toxins!

• Exotoxins

– A/B

– Pore-forming

– Superantigen

• Endotoxin Inflammatory Response

  • Acute
  • Chronic
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13
Q

A/B Toxins

A
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14
Q

Membrane Active Exotoxins

A

• Cytotoxins

– pore forming

– Inserts in lipid bilayer

– Leakage of essential components

– Osmotic instability

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15
Q

Superantigen Toxins

A
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16
Q

Protein (Toxin) Secretion

17
Q

Endotoxin - LPS

18
Q

Inflammation

19
Q

Genetics of Virulence

Study These Flashcards
A
  • Genetic evolution
  • Regulation
  • Pathogenicity island
20
Q

Genetic Evolution

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A

• Chromosome

– Homologous recombination/ transformation

– Transposon

• Gene transfer

– Virulence plasmids

* Conjugation

* Transduction

21
Q

Regulation

Study These Flashcards
A
  • Operons/regulons
  • 2-component systems
22
Q

Pathogenicity Island

I & I Part III
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