benzodiazepines

Question 1

uses

Answer 1

sedation 
hypnotic 
anxiolytic 
anticonvulsant 
muscle relaxant

Question 2

withdrawing benzodizepines

Answer 2

withdrawn in steps of ~1/8 of daily dose every 14days

Question 3

suggested protocol for withdrawal

Answer 3

• switch pt to equivalent dose of diazepam

- reduce dose diazepem by 2/2.5mg every 2-3wks

Question 4

benzodiazepine MOA

Answer 4

enhance effect of inhibitory GABA by increasing frequency of chloride channels

Question 5

barbituates MOA

Answer 5

enhance effect inhibitory GABA by increasing duration of chloride channel opening