BJUI

Question 1

Define ERECTILE DYSFUNCTION

Answer 1

The persistent inability to achieve and maintain an erection sufficient to provide adequate sexual activity

Question 2

Quantification of severity of ED can be quantified using the _____

Answer 2

International Index of Erectile Function score

Question 3

Describes the kind of ED caused by:
- Impairment of the endothelium-dependent relaxation of the smooth muscle
- Occlusion of cavernous arteries due to atherosclerosis
- Combination of both

Answer 3

Vasculogenic ED

Question 4

How do PDE5 inhibitors work?

Answer 4

By inhibition of the PDE5 enzyme, the cGMP concentration will be raised and can increase the relaxation of smooth muscles.

Question 5

Sildenafil was the first available PDE5 inhibitor. It is metabolized at the hepatic level thus can be affected by CYP3A4 inhibitors leading to increases plasma concentration.

What are clinically important CYP3A4 inhibitors?

Answer 5

Itraconazaole
Ketoconazole
Clarithromycin
Erythromycin
Nefazodone
Grapefruit juice

Question 6

What has a longer duration of action — Sildenafil or Tadalafil?

Answer 6

Tadalafil

Half life of Tadalafil is at 17 hrs compared for the 4 hrs of Sildenafil or Vardenafil. Moreso, a high fat meal has no impact on Tadalafil.