Blastomyces

Question 1

How do you find candidate factors?

Answer 1

mix antigens with patient serum that contains antibodies

Question 2

What does BAD1 stand for?

Answer 2

Blastomyces ADhesion 1

Question 3

What do BAD1 do?

Answer 3

• adhere to macrophage
• DOWN TNFalpha (proinflam) via secreted BAD1

Question 4

What does DRK1 stand for?

Answer 4

Dimorphic Regulating Kinase 1

Question 5

What do DRK1 do?

Answer 5

turns on BAD1 and allows blasto to turn into yeast

Question 6

How did they find DRK1?

Answer 6

looked for mutants that don’t express BAD1 but still grow