1
Q
What type of patients do BBs lower BP?
A
hypertensive pts
NOT normotensive pts!!
2
Q
Possible mechanism…
A
reduction of renin release from JGA
problems w/ this theory empirically based on plasma renin levels
3
Q
Presynaptic autoreceptors…
A
enhance NE release
4
Q
Long-term administration ultimately leads to…
A
fall in peripheral vascular resistance (MOA unknown)
5
Q
Central CNS effects?
A
but drugs that poorly penetrate BBB are effective antihypertensives
