1
Q
Main drugs
A
Propranolol
acebutolol
carvedilol
2
Q
Drugs with this capability are…
A
Class I antiarrhythmic compounds
according to Vaughan-Williams classification
3
Q
MOA
A
bind and block fast Na channels responsible for phase 0 of fast-response cardiac action potentials
4
Q
Results of MOA
A
decreases slope of phase 0–>
decrease in amplitude of action potential
5
Q
Other characteristics
A
non-nodal, cardiomyocytes (i.e. atrial and ventricular myocytes; purkinje tissue)
