Breast

Question 1

What percentage of cancers are ER positive and Her2 positive?

Answer 1

• 70-80% ER positive

- 20% Her2 positive

Question 2

Differentiate between large duct and small duct papillomas

Answer 2

• Large ducts usually solitary and located in lactiferous sinuses of nipple
• Small ducts typically multiple and located deeper in the breast, possibly higher risk for carcinoma

Question 3

What are the relative risks of developing cancer in various breast diseases?

Answer 3

Non-proliferative disease: 1.0
Proliferative without atypia (e.g. complex sclerosing lesions, papilloma): 1.5-2
Proliferative disease with atypia (ADH, ALH): 4-5
DCIS/LCIS: 8-10 (25-30% lifetime risk)

Question 4

How many DCIS and LCIS cases are bilateral

Answer 4

DCIS: 10-20%
LCIS: 20-40%

Question 5

What is the immunoprofile of PASH?

Answer 5

• usually ER/PR positive
• CD34 positive, variable actin positivity
• negative for CD31, FVIII

Question 6

What are distinctive features of male breast cancer?

Answer 6

• often associated with BRCA2 mutation
• more frequently papillary
• not usually lobular
• more often ER positive