Chapter 17: GI

Question 1

Meckel diverticulum is from failed involution of what?

Answer 1

Vitelline duct (which connects GI lumen to yolk sac)

Question 2

What syndromes are associated with pyloric stenosis?

Answer 2

Turner syndrome, trisomy 18

Question 3

Facts about Hirschprungs disease

Answer 3

• premature arrest of neural crest cell migration from cecum to rectum
• lack of Meissner submucosal and Auerbach myenteric plexes
• due to loss of function mutations in RET
• associated with Down syndrome

Question 4

What are some genetic abnormalities seen in esophageal adenocarcinoma?

Answer 4

Early: p53 mutation
Later: Her2, cyclin D1, cyclinE amplification, RB mutation and p16 loss

Question 5

Differentiate Curling and Cushing ulcers

Answer 5

Curling: proximal duodenum, associated with burns and trauma
Cushing: gastric, duodenal and esophageal, associated with intracranial disease and high risk of perforation