Sarcomas with lymph node metastasis
Clear cell sarcoma
Epithelioid sarcoma
Alveolar rhabdomyosarcoma
Synovial sarcoma
Angiosarcoma
Common locations of inflammatory myofibroblastic tumor
Mesentery, omentum, retroperitoneum most common
Can also happen in H&N, lung, bladder, gyne, CNS
Histologic patterns of inflammatory myofibroblastic tumors
Spindle/stellate cells with loose myxoid stroma
Compact spindles in fascicles/storiform pattern
Hypocellular sclerotic matrix
Sites of embryonal rhabdomyosarcoma
GU (bladder, prostate, peritesticular soft tissue)
H&N (orbit, oropharynx, sinus, tongue, middle ear)
Biliary tract
CK+ sarcomas
Epithelioid sarcoma
Desmoplastic small round cell tumor
Chordoma
Biphasic synovial sarcoma
Adamantinoma-like variant of Ewing sarcoma
Epithelioid hemangioendothelioma
Cd34+ non-vascular tumors
SFT
DFSP
GIST
Epithelioid sarcoma
Nerve sheath tumors
Myeloid neoplasms
Possible lines of differentiation in spindle cell tumors
Muscle
Nerve sheath
Vascular
Myofibroblastic
FIbrohistiocytic
Adipocytic
Others: GIST, SFT, SS, Carcinoma, melanoma
Grading treatment effect in Ewing’s sarcoma
Grade 1: 0% necrosis
Grade 2A: <50% necrosis
Grade 2B; 50-95% necrosis
Grade 3: 96-99% necrosis
Grade 4: 100% necrosis
Most common histologic patterns of conventional osteosarcoma
Osteoblastic
Chondroblastic
Fibroblastic
Telangiectatic is rare
Small cell
Subtypes of surface osteosarcoma
Parosteal
Periosteal
High grade surface osteosarcoma
