Carbamates
pesticides derived from carbamic acid and kill insects similar to Organophosphates
Absorption of Carbamates?
Inhalation
Ingestion
Toxicokinetics of Carbamates
DO NOT penetrate the CNS
DO NOT require hepatic bioactivation
Mechanism of Action for Carbamates?
Reversible inhibition of acetylcholinesterase
Clinical signs of Carbamates
Salivation
Lacrimation
Urination
Diarrhea
“SLUD”
Laboratory Diagnosis of Carbamates
Blood samples
Diagnosis of Carbamate toxicosis
History of exposure
Response to Atropine Therapy
Treatment of Carbamate toxicosis
Atropine
Prognosis of Carbamates
Good if treatment is started soon